Torin1

CAS No. 1222998-36-8

Torin1( Torin 1 | Torin-1 )

Catalog No. M10848 CAS No. 1222998-36-8

Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 37 In Stock
5MG 60 In Stock
10MG 87 In Stock
50MG 295 In Stock
100MG 447 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Torin1
  • Note
    Research use only, not for human use.
  • Brief Description
    Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM.
  • Description
    Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM); exhibits 100-fold binding selectivity relative to 450 other protein kinases; causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin; prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.(In Vitro):Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK.(In Vivo):Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues.
  • In Vitro
    Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK.
  • In Vivo
    Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues.
  • Synonyms
    Torin 1 | Torin-1
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    DNA-PK|mTOR|mTORC1|mTORC2|p110γ
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1222998-36-8
  • Formula Weight
    607.6243
  • Molecular Formula
    C35H28F3N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6.6 mg/mL (Need ultrasonic or warming)
  • SMILES
    O=C1N(C2=CC=C(N3CCN(C(CC)=O)CC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC7=CC=CC=C7N=C6)C=C54)C=C1
  • Chemical Name
    Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thoreen CC, et al. J Biol Chem. 2009 Mar 20;284(12):8023-32. 2. Liu Q, et al. J Med Chem. 2010 Oct 14;53(19):7146-55. 3. Weichhart T, et al. Blood. 2011 Apr 21;117(16):4273-83. 4. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6.
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