
Torin1
CAS No. 1222998-36-8
Torin1( Torin 1 | Torin-1 )
Catalog No. M10848 CAS No. 1222998-36-8
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 37 | In Stock |
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5MG | 60 | In Stock |
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10MG | 87 | In Stock |
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50MG | 295 | In Stock |
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100MG | 447 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameTorin1
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NoteResearch use only, not for human use.
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Brief DescriptionTorin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM.
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DescriptionTorin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM); exhibits 100-fold binding selectivity relative to 450 other protein kinases; causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin; prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.(In Vitro):Torin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK.(In Vivo):Torin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues.
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In VitroTorin1 (250 nM) completely inhibits proliferation and causes a G1/S cell cycle arrest, and decreases cell size to a greater degree than 50 nM rapamycin in wild-type MEFs. Torin1 has more than 800-fold selectivity between mTOR and PI3Kis, and is very selective relative to other PIKK family kinases with the exception of DNA-PK.
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In VivoTorin1 (20 mg/kg, i.p.) is efficacious in a U87MG xenograft model, and demonstrates good pharmacodynamic inhibition of downstream effectors of mTOR in tumor and peripheral tissues.
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SynonymsTorin 1 | Torin-1
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptorDNA-PK|mTOR|mTORC1|mTORC2|p110γ
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1222998-36-8
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Formula Weight607.6243
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Molecular FormulaC35H28F3N5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 6.6 mg/mL (Need ultrasonic or warming)
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SMILESO=C1N(C2=CC=C(N3CCN(C(CC)=O)CC3)C(C(F)(F)F)=C2)C4=C(C=NC5=CC=C(C6=CC7=CC=CC=C7N=C6)C=C54)C=C1
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Chemical NameBenzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Thoreen CC, et al. J Biol Chem. 2009 Mar 20;284(12):8023-32.
2. Liu Q, et al. J Med Chem. 2010 Oct 14;53(19):7146-55.
3. Weichhart T, et al. Blood. 2011 Apr 21;117(16):4273-83.
4. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6.
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