Toosendanin( —— )

Catalog No. M18857 CAS No. 58812-37-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Toosendanin
Note

Research use only, not for human use.
Brief Description

Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells.
Description

Toosendanin possesses hepatotoxicity. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. Toosendanin is an effective insecticide for Ae.
In Vitro

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In Vivo

Toosendanin (0.5 and 1 mg/kg, Intraperitoneal injection daily for 7 days) alleviates DSS-induced experimental colitis by inhibiting M1 macrophage polarization and regulating NLRP3 inflammasome and Nrf2/HO-1 signaling, and may provide a novel Chinese patent medicine for the treatment of murine colitis. Animal Model:Forty-eight male C57BL/6 mice weighing 20-22 g.Dosage:0.5 and 1 mg/kg.Administration:Intraperitoneal injection daily for 7 days.Result:Protected against DSS-induced colitis in mice.Inhibited the expression of proinflammatory cytokines in DSS-induced UC and improved oxidative stress.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

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CAS Number

58812-37-6
Formula Weight

574.62
Molecular Formula

C30H38O11
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (174.03 mM)
SMILES

CC(=O)OC1CC(C23COC(C1(C2CC(C4(C3C(=O)C(C5(C46C(O6)CC5C7=COC=C7)C)OC(=O)C)C)O)C)O)O
Chemical Name

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