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Tomatine

CAS No. 17406-45-0

Tomatine( lycopersicin )

Catalog No. M19426 CAS No. 17406-45-0

An antiproliferatve agent of breast adenocarcinoma cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tomatine
  • Note
    Research use only, not for human use.
  • Brief Description
    An antiproliferatve agent of breast adenocarcinoma cells.
  • Description
    Tomatine is a glycoalkaloid found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    lycopersicin
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    17406-45-0
  • Formula Weight
    1034.2
  • Molecular Formula
    C50H83NO21
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:96.7 mM
  • SMILES
    C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)[C@H]3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)O[C@@]11CC[C@H](C)CN1
  • Chemical Name
    (2S3R4S5S6R)-2-(((2S3R4S5R6R)-2-(((2R3R4R5R6R)-45-dihydroxy-2-(hydroxymethyl)-6-(((2aS4S5'S6aS6bS8aS8bR9S10S11aS12aS12bR)-5'6a8a9-tetramethyloctadecahydrospiro[naphtho[2'1':45]indeno[21-b]furan-102'-piperidin]-4-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-5-hydroxy-6-(hydroxymethyl)-4-(((2S3R4S5R)-345-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-345-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bretschneider A. et al. Know your ABCs: Characterization and gene expression dynamics of ABC transporters in the polyphagous herbivore Helicoverpa armigera. Insect Biochem Mol Biol. 2016 May;72:1-9.
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