Tirapazamine

Research use only, not for human use.

Tirapazamine is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks.

Trapazamine, also known as SR-4233,DNA-damaging drug potentially for the treatment of cervical carcinoma, head and neck cancer. Tirapazamine is activated to its toxic form preferentially in the hypoxic areas of solid tumors. Cells in these regions are resistant to killing by radiotherapy and most anticancer drugs. Thus the combination of tirapazamine with conventional anticancer treatments is particularly effective.

Tirapazamine; Tirazone; SR 4233; SR-4233; WIN 59075

Others

Other Targets

Others

Cancer

——

27314-97-2

178.15

C7H6N4O2

97%

DMSO : ≥ 39 mg/m; 218.92 mM

Nc1nn(=O)c2ccccc2n1=O

3-aminobenzo[e][1,2,4]triazine 1,4-dioxide

(-20℃)

With Ice Pack

≥ 2 years