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ThioLox
CAS No. 1202193-89-2
ThioLox( —— )
Catalog No. M36069 CAS No. 1202193-89-2
ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 46 | Get Quote |
|
| 10MG | 77 | Get Quote |
|
| 25MG | 165 | Get Quote |
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| 50MG | 273 | Get Quote |
|
| 100MG | 467 | Get Quote |
|
| 500MG | 1008 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameThioLox
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NoteResearch use only, not for human use.
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Brief DescriptionThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with an IC50 value of 12 μM, demonstrating significant anti-inflammatory and neuroprotective properties, including strong protection against glutamate toxicity.
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DescriptionThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties.
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In VitroRT-PCRCell Line:Precision-cut lung slices (PCLS) Concentration:1, 5, 10, 25 and 50 μM Incubation Time:In combination with 10 μM linoleic acid for 20 h and stimulated with 10 ng/mL LPS for the last 4 h.Result:Provided almost 50% inhibition of the expression of the pro-inflammatory genes IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS at 50 μM.Cell Viability Assay Cell Line:Neuronal HT-22 cells Concentration:5, 10 and 20 μMIncubation Time:14-16 h Result:Significantly reduced neuronal cell death against glutamate toxicity.
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In Vivo——
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Synonyms——
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PathwayImmunology/Inflammation
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TargetLipoxygenase
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RecptorLipoxygenase
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Research Area——
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Indication——
Chemical Information
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CAS Number1202193-89-2
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Formula Weight274.38
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Molecular FormulaC15H18N2OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (364.46 mM; Ultrasonic (<60°C)
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SMILESC(NCCCC)(=O)C=1C=C(SC1N)C2=CC=CC=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Eleftheriadis N, et al. Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties. Eur J Med Chem. 2016 Oct 21;122:786-801.?
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