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Thalidomide-NH-C2-PEG3-OH
CAS No. 2140807-23-2
Thalidomide-NH-C2-PEG3-OH( H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- )
Catalog No. M28647 CAS No. 2140807-23-2
Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 302 | Get Quote |
|
| 10MG | 447 | Get Quote |
|
| 25MG | 714 | Get Quote |
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| 50MG | 1017 | Get Quote |
|
| 100MG | 1368 | Get Quote |
|
| 500MG | 2673 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameThalidomide-NH-C2-PEG3-OH
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NoteResearch use only, not for human use.
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Brief DescriptionThalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
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DescriptionThalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate.
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In VitroXZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis.
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In Vivo——
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SynonymsH-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
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PathwayOthers
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TargetOther Targets
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RecptorCYP4A|20-Hydroxyeicosatetraenoic acid(20-HETE) synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number2140807-23-2
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Formula Weight449.45
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Molecular FormulaC21H27N3O8
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Purity>98% (HPLC)
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Solubility——
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SMILESOCCOCCOCCOCCNc1cccc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nakamura T, et al. Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6.
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