Thalidomide-5-methyl

CAS No. 40313-92-6

Thalidomide-5-methyl ( —— )

Catalog No. M28307 CAS No. 40313-92-6

Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 393 Get Quote
10MG 581 Get Quote
25MG 888 Get Quote
50MG 1242 Get Quote
100MG 1674 Get Quote
500MG 3348 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Thalidomide-5-methyl
  • Note
    Research use only, not for human use.
  • Brief Description
    Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.
  • Description
    Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hDHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40313-92-6
  • Formula Weight
    272.3
  • Molecular Formula
    C14H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc(cc1)cc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lewis TA, et al. Development?of?ML390: A?Human?DHODH?Inhibitor?That?Induces?Differentiation?in?Acute?Myeloid?Leukemia. ACS Med Chem Lett.?2016 Sep 28;7(12):1112-1117.
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