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Thalidomide-5-methyl

CAS No. 40313-92-6

Thalidomide-5-methyl( —— )

Catalog No. M28307 CAS No. 40313-92-6

Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Thalidomide-5-methyl
  • Note
    Research use only, not for human use.
  • Brief Description
    Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.
  • Description
    Thalidomide-5-methyl is the Thalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hDHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    40313-92-6
  • Formula Weight
    272.26
  • Molecular Formula
    C14H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc(cc1)cc(C(N2C(CCC(N3)=O)C3=O)=O)c1C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lewis TA, et al. Development?of?ML390: A?Human?DHODH?Inhibitor?That?Induces?Differentiation?in?Acute?Myeloid?Leukemia. ACS Med Chem Lett.?2016 Sep 28;7(12):1112-1117.
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