Tenatoprazole ( TU-199; Tenatoprazole; Ulsacare; Protop )

Catalog No. M17835 CAS No. 113712-98-4

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Product Name

Tenatoprazole
Note

Research use only, not for human use.
Brief Description

Tenatoprazole, a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).
Description

Tenatoprazole, also known as TU-199, is a proton pump inhibitor drug candidate that was undergoing clinical testing as a potential treatment for reflux oesophagitis and peptic ulcer. Tenatoprazole has an imidazopyridine ring in place of the benzimidazole moiety found in other proton pump inhibitors, and has a half-life about seven times longer than other PPIs.
Synonyms

TU-199; Tenatoprazole; Ulsacare; Protop
Pathway

Others
Target

Other Targets
Recptor

Proton pump
Research Area

Inflammation/Immunology
Indication

——

CAS Number

113712-98-4
Formula Weight

346.4
Molecular Formula

C16H18N4O3S
Purity

98%
Solubility

——
SMILES

COc1ccc2[nH]c(nc2n1)S(=O)Cc1c(C)c(OC)c(C)cn1
Chemical Name

5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-imidazo[4,5-b]pyridine

1. Shin JM, et al. Biochem Pharmacol, 2006, 71(6), 837-849.

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