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Teglicar

CAS No. 250694-07-6

Teglicar ( ST-1326;ST1326 )

Catalog No. M13738 CAS No. 250694-07-6

Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Teglicar
  • Note
    Research use only, not for human use.
  • Brief Description
    Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM.
  • Description
    Teglicar (ST-1326) is a potent, selective and reversible inhibitor of liver carnitine palmitoyl-transferase 1 (L-CPT1) with IC50 of 0.68 uM, Ki of 0.36 uM; displays an extraordinarily high selectivity (39-fold) toward the liver isoform over the heart isoform (muscle-CPT1;M-CPT1); reduces gluconeogenesis and improves glucose homeostasis, shows antiketotic and antidiabetic activity in diabetic db/db mice; also inhibits fatty acid oxidation associated with cell growth arrest, mitochondrial damage, and apoptosis induction in leukemia cell lines; orally active.Diabetes Phase 2 Discontinued
  • Synonyms
    ST-1326;ST1326
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    250694-07-6
  • Formula Weight
    399.62
  • Molecular Formula
    C22H45N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCCCCCCCCCCCCNC(=O)NC(CC(=O)[O-])C[N+](C)(C)C
  • Chemical Name
    (R)-4-Trimethylammonio-3-[(tetradecylcarbamoyl)amino]butyrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ricciardi MR, et al. Blood. 2015 Oct 15;126(16):1925-9.
2. Giannessi F, et al. J Med Chem. 2003 Jan 16;46(2):303-9.
3. Conti R, et al. Diabetes. 2011 Feb;60(2):644-51.
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