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Taranabant

CAS No. 701977-09-5

Taranabant ( MK-0364;MK0364 )

Catalog No. M15694 CAS No. 701977-09-5

A potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Taranabant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.
  • Description
    A potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM; displays >1000-fold selectivity over CB2R (Ki=170 nM), AT1R, NK2R, A3R, MT1R, D1R, etc.; dose-dependently inhibits food intake and weight gain in diet-induced obese (DIO) rats with an acute minimum effective dose of 1 mg/kg and has good pharmacokinetic.Obesity Phase 3 Discontinued
  • Synonyms
    MK-0364;MK0364
  • Pathway
    GPCR/G Protein
  • Target
    Cannabinoid Receptor
  • Recptor
    Cannabinoid Receptor
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    701977-09-5
  • Formula Weight
    515.95
  • Molecular Formula
    C27H25ClF3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 42 mg/mL
  • SMILES
    CC(OC1=NC=C(C(F)(F)F)C=C1)(C)C(N[C@H]([C@H](C2=CC=CC(C#N)=C2)CC3=CC=C(Cl)C=C3)C)=O
  • Chemical Name
    Propanamide, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Armstrong HE, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2184-7.
2. Fong TM, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1013-22.
3. Addy C, et al. Cell Metab. 2008 Jan;7(1):68-78.
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