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Taranabant
CAS No. 701977-09-5
Taranabant ( MK-0364;MK0364 )
Catalog No. M15694 CAS No. 701977-09-5
A potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 858 | Get Quote |
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| 100MG | 1296 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTaranabant
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM.
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DescriptionA potent, selective and orally active cannabinoid-1 receptor (CB1R) inverse agonist with IC50 of 2.8 nM, Ki of 0.13 nM; displays >1000-fold selectivity over CB2R (Ki=170 nM), AT1R, NK2R, A3R, MT1R, D1R, etc.; dose-dependently inhibits food intake and weight gain in diet-induced obese (DIO) rats with an acute minimum effective dose of 1 mg/kg and has good pharmacokinetic.Obesity Phase 3 Discontinued
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SynonymsMK-0364;MK0364
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PathwayGPCR/G Protein
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TargetCannabinoid Receptor
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RecptorCannabinoid Receptor
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Research AreaMetabolic Disease
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IndicationObesity
Chemical Information
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CAS Number701977-09-5
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Formula Weight515.95
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Molecular FormulaC27H25ClF3N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 42 mg/mL
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SMILESCC(OC1=NC=C(C(F)(F)F)C=C1)(C)C(N[C@H]([C@H](C2=CC=CC(C#N)=C2)CC3=CC=C(Cl)C=C3)C)=O
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Chemical NamePropanamide, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)-2-pyridinyl]oxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Armstrong HE, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2184-7.
2. Fong TM, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1013-22.
3. Addy C, et al. Cell Metab. 2008 Jan;7(1):68-78.
2. Fong TM, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1013-22.
3. Addy C, et al. Cell Metab. 2008 Jan;7(1):68-78.
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