Taltirelin
CAS No. 103300-74-9
Taltirelin ( TA-0910 )
Catalog No. M22035 CAS No. 103300-74-9
Taltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 45 | In Stock |
|
10MG | 73 | In Stock |
|
50MG | 284 | In Stock |
|
100MG | 510 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameTaltirelin
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NoteResearch use only, not for human use.
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Brief DescriptionTaltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
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DescriptionTaltirelin is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].Taltirelin (TAL), in mouse models of CRF.?To model fatigue, we used a mouse model of chemotherapy, a mouse model of radiation therapy, and mice bearing colon 26 carcinoma tumors.?We used the treadmill fatigue test to assess fatigue-like behavior after treatment with TAL.?Additionally, we used wild-type and TRH receptor knockout mice to determine which TRH receptor was necessary for the actions of TAL.?Tumor-bearing mice displayed muscle wasting and all models caused fatigue-like behavior, with mice running a shorter distance in the treadmill fatigue test than controls.?TAL reversed fatigue-like behavior in all three models and the mouse TRH1 receptor was necessary for the effects of TAL.?These data suggest that TAL may be useful in alleviating fatigue in all cancer patients and provide further support for evaluating TAL as a potential therapy for CRF in humans.
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SynonymsTA-0910
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PathwayOthers
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TargetOther Targets
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RecptorThyrotropin-releasing hormone receptor
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Research AreaNervous system
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IndicationSpinocerebellar Degeneration
Chemical Information
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CAS Number103300-74-9
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Formula Weight405.41
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Molecular FormulaC17H23N7O5
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Purity>98% (HPLC)
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SolubilityDMSO:30 mg/mL (74 mM)
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SMILESCN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N1CCC[C@H]1C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dougherty J P , Wolff B S , Cullen M J , et al. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue.[J]. Pharmacological Research, 2017, 124:1-8.
molnova catalog
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