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Talniflumate

CAS No. 66898-62-2

Talniflumate( Talniflumate )

Catalog No. M18975 CAS No. 66898-62-2

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Talniflumate
  • Note
    Research use only, not for human use.
  • Brief Description
    Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture.
  • Description
    Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.(In Vivo):Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction.
  • In Vitro
    ——
  • In Vivo
    Talniflumate (oral chow; 0.4 mg/g; 21 days) significantly increases CF mouse survival from 26 to 77%. It does not alter crypt goblet cell numbers or change intestinal expression of mCLCA3 but tends to decrease crypt mucoid impaction. Animal Model:CF mice with distal intestinal obstructive syndrome (DIOS)Dosage:0.4 mg/g Administration:Oral chow; 21 days Result:Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome.
  • Synonyms
    Talniflumate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    hCLCA1/mCLCA3|COX|Cl-/HCO3- exchanger|GCNT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66898-62-2
  • Formula Weight
    414.33
  • Molecular Formula
    C21H13F3N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (150.85 mM)
  • SMILES
    FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
  • Chemical Name
    2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.
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