Talniflumate ( Talniflumate )

Catalog No. M18975 CAS No. 66898-62-2

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Product Name

Talniflumate
Note

Research use only, not for human use.
Brief Description

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture.
Description

Talniflumate is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.
Synonyms

Talniflumate
Pathway

Others
Target

Other Targets
Recptor

hCLCA1/mCLCA3;COX;Cl-/HCO3- exchanger;GCNT3
Research Area

——
Indication

——

CAS Number

66898-62-2
Formula Weight

414.33
Molecular Formula

C21H13F3N2O4
Purity

98%
Solubility

——
SMILES

FC(F)(F)c1cccc(Nc2ncccc2C(=O)OC2OC(=O)c3ccccc23)c1
Chemical Name

2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

1. Knight D. Talniflumate (Genaera)[J]. Current Opinion in Investigational Drugs, 2004, 5(5):557-62.

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