TY-52156

Research use only, not for human use.

TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor.

TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM). TY-52156 displays submicromolar potency and a high degree of selectivity for the S1P3 receptor. TY-52156 inhibits the S1P3 receptor-dependent increase in [Ca2+]i. TY-52156 (10 μM; 10 min) inhibits S1P-induced p44/p42 MAPK phosphorylation.After oral administration in vivo, TY-52156 (10 mg/kg, 30 mg/kg; p.o.) inhibits S1P3 receptor-induced bradycardia.

Western Blot Analysis Cell Line:Chinese hamster ovary K1 cells Concentration:10 μM Incubation Time:10 min Result:Inhibited S1P-induced p44/p42 MAPK phosphorylation.

Animal Model:Male SD rats (290–340 g)Dosage:10 mg/kg, 30 mg/kg Administration:Oral administration Result:Inhibited S1P3 receptor-induced bradycardia after oral administration in vivo.

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GPCR/G Protein

S1P Receptor

S1P3

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934369-14-9

364.27

C18H19Cl2N3O

>98% (HPLC)

DMSO:100 mg/mL (274.52 mM)

CC(C)(C)C(=O)C(\NNc1ccc(Cl)cc1)=N\c1ccc(Cl)cc1

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(-20℃)

With Ice Pack

≥ 2 years