TXNIP-IN-1

CAS No. 1268955-50-5

TXNIP-IN-1 ( —— )

Catalog No. M26491 CAS No. 1268955-50-5

TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 260 Get Quote
10MG 394 Get Quote
25MG 653 Get Quote
50MG 888 Get Quote
100MG 1242 Get Quote
500MG 2493 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    TXNIP-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.
  • Description
    TXNIP-IN-1 is an inhibitor of the TXNIP-TRX complex and used in the research of TXNIP-TRX complex associated metabolic disorder (diabetes), cardiovascular disease, or inflammatory disease.(In Vitro):In monocytes, TXNIP-IN-1 (1.25-5 μM) reduces HG-induced expression of TNF. TXNIP-IN-1 bocks high glucose (HG-induced) TXNIP-TRX complex formation. TXNIP-IN-1 (5 μM; 16-72 hours) inhibits c-TRX interaction in THP1 cells cultured in 25mM glucose. TXNIP-IN-1 targets TXNIP mRNA in human pancreatic islets. In THP1 cells, TXNIP-IN-1 (1.25-5 μM; 72 hours) inhibits TXNIP mRNA expression. TXNIP-IN-1 (0.3-10 μM; 72 hours) inhibits TXNIP mRNA expression in murine RAW macrophages. In MIN6 cells, TXNIP-IN-1 (5-20 μM; 72 hours) decreases TXNIP but not TNF-alpha mRNA levels. TXNIP-IN-1 (0.62-5 μM; 72 hours) affects TXNIP and TNF-alpha mRNA expression in the human pancreas 1.1B4 beta cells.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1268955-50-5
  • Formula Weight
    248.2
  • Molecular Formula
    C12H12N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C(N1C(=O)c2ccncc2C1=O)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xiong Li, et al. A new cytisine-type alkaloid from the stem bark of Maackia amurensis. Nat Prod Res. 2010 Oct;24(16):1499-502.
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