TUG-424

Research use only, not for human use.

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).(In Vitro):In the presence of the same glucose concentration, the approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate. Increasing concentrations (100 nM to 10 μM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 μM. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424 .

TUG424

Others

Other Targets

Human Endogenous Metabolite

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1082058-99-8

264.3

C18H16O2

>98% (HPLC)

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Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years