TS-011

Research use only, not for human use.

TS-011 is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

TS-011 is a selective 20-Hydroxyeicosatetraenoic acid synthesis inhibitor.

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TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05). In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%.

N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide

Others

Other Targets

20-Hydroxyeicosatetraenoic acid synthesis

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339071-18-0

255.7

C11H14ClN3O2

>98% (HPLC)

DMSO : 240 mg/mL?(938.60 mM;?Need ultrasonic)

ON=CNc(cc1)cc(Cl)c1N1CCOCC1

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(-20℃)

With Ice Pack

≥ 2 years