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TRi-1

CAS No. 246020-68-8

TRi-1 ( —— )

Catalog No. M20217 CAS No. 246020-68-8

TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 86 In Stock
5MG 132 In Stock
10MG 205 In Stock
25MG 340 In Stock
50MG 484 In Stock
100MG 700 In Stock
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Biological Information

  • Product Name
    TRi-1
  • Note
    Research use only not for human use.
  • Brief Description
    TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
  • Description
    TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TXNRD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    246020-68-8
  • Formula Weight
    328.72
  • Molecular Formula
    C12H9ClN2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL?(190.13 mM)
  • SMILES
    COc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stafford WC et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.
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