TRi-1 ( —— )

Catalog No. M20217 CAS No. 246020-68-8

TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	205	In Stock
25MG	340	In Stock
50MG	484	In Stock
100MG	700	In Stock
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Biological Information

Product Name

TRi-1
Note

Research use only not for human use.
Brief Description

TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
Description

TRi-1 is irreversible inhibitor of?cytosolic thioredoxin reductase 1 (TXNRD1) with an?IC50?of 12 nM. TRi-1 has little mitochondrial toxicity for anticancer therapy.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TXNRD1
Research Area

——
Indication

——

Chemical Information

CAS Number

246020-68-8
Formula Weight

328.72
Molecular Formula

C12H9ClN2O5S
Purity

>98% (HPLC)
Solubility

DMSO:62.5 mg/mL?(190.13 mM)
SMILES

COc1ccc(c(n1)S(=O)(=O)c1ccc(Cl)cc1)[N+]([O-])=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Stafford WC et al. Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy. Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444.

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