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TRPM4-IN-2

CAS No. 667411-04-3

TRPM4-IN-2( —— )

Catalog No. M35537 CAS No. 667411-04-3

TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TRPM4-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4).
  • Description
    TRPM4-IN-2 (NBA) is a potent transient receptor potential melastatin 4 (TRPM4) inhibitor with an IC50 value of 0.16 μM. TRPM4-IN-2 can be used for researching prostate cancer and colorectal cancer.
  • In Vitro
    TRPM4-IN-2 (NBA) (50 μM; 0-500 s) blocks the endogenous TRPM4 currents in DU145.Cell Proliferation Assay Cell Line:DU145 Concentration:50 μM Incubation Time:0-500 s Result:Blocked 88 ± 9% of the endogenous TRPM4 currents at 50 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    667411-04-3
  • Formula Weight
    355.77
  • Molecular Formula
    C19H14ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (281.08 mM)
  • SMILES
    O(CC(NC1=C(C(O)=O)C=CC(Cl)=C1)=O)C=2C3=C(C=CC2)C=CC=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Borgstr?m A, et al. Small Molecular Inhibitors Block TRPM4 Currents in Prostate Cancer Cells, with Limited Impact on Cancer Hallmark Functions. J Mol Biol. 2021 Aug 20;433(17):166665.?
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