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TRAP-6(2TFA)

CAS No. 141136-83-6

TRAP-6(2TFA)( PAR-1 agonist peptide | Thrombin Receptor Activator Peptide 6 )

Catalog No. M21039 CAS No. 141136-83-6

TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 43 Get Quote
5MG 72 Get Quote
10MG 115 Get Quote
25MG 259 Get Quote
50MG 390 Get Quote
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Biological Information

  • Product Name
    TRAP-6(2TFA)
  • Note
    Research use only, not for human use.
  • Brief Description
    TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
  • Description
    TRAP-6(2TFA) is an agonist of protease-activated receptor 1 (PAR1).
  • In Vitro
    TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1.?TRAP-6 (0.01-10 μM; 30 min) activates human platelets.?TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane.
  • In Vivo
    TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats.
  • Synonyms
    PAR-1 agonist peptide | Thrombin Receptor Activator Peptide 6
  • Pathway
    GPCR/G Protein
  • Target
    PAR
  • Recptor
    PAR-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    141136-83-6
  • Formula Weight
    748.87
  • Molecular Formula
    C34H56N10O9
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:28 mg/mL (37.39 mM) ; H2O:33.33 mg/mL (44.51 mM)
  • SMILES
    CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(N)CO)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(N)=O)C(=O)O
  • Chemical Name
    L-seryl-L-phenylalanyl-L-leucyl-L-leucyl-L-arginyl-L-asparagine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Weber M Gerdsen F Gutensohn K et al. Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism[J]. Thrombosis Research 2002 107(6):0-328.
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