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TQS

CAS No. 353483-92-8

TQS( 4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide )

Catalog No. M24306 CAS No. 353483-92-8

TQS is a positive allosteric modulator of α7 nACh receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 43 In Stock
5MG 68 In Stock
10MG 110 In Stock
25MG 237 In Stock
50MG 383 In Stock
100MG 565 In Stock
500MG 1215 In Stock
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Biological Information

  • Product Name
    TQS
  • Note
    Research use only, not for human use.
  • Brief Description
    TQS is a positive allosteric modulator of α7 nACh receptors.
  • Description
    TQS is a positive allosteric modulator of α7 nACh receptors.
  • In Vitro
    ——
  • In Vivo
    TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus. Animal Model:Male C57BL/6J miceDosage:1 or 4 mg/kg Administration:I.p.Result:Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.
  • Synonyms
    4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    353483-92-8
  • Formula Weight
    376.47
  • Molecular Formula
    C22H20N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 240 mg/mL?(637.50 mM;?Need ultrasonic)
  • SMILES
    NS(c(cc1)cc(C2C=CCC22)c1NC2c1cccc2ccccc12)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Muzaffar A , Sami A , Papke R L , et al. The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice[J]. Drug Discoveries & Therapeutics, 2017, 11(4):206-211.
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