TPI-1

Research use only, not for human use.

TPI-1 is a SHP-1 inhibitor.

TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.

TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1

Others

Other Targets

recombinant SHP-1

Cancer

——

79756-69-7

253.08

C12H6Cl2O2

98%

DMSO : 50 mg/mL 197.57 mM;

c1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl

2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione

(-20℃)

With Ice Pack

≥ 2 years