TPI-1
CAS No. 79756-69-7
TPI-1 ( TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1 )
Catalog No. M17598 CAS No. 79756-69-7
TPI-1 is a SHP-1 inhibitor.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 63 | In Stock |
|
5MG | 105 | In Stock |
|
10MG | 178 | In Stock |
|
25MG | 348 | In Stock |
|
50MG | 529 | In Stock |
|
100MG | 754 | In Stock |
|
500MG | 1548 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTPI-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionTPI-1 is a SHP-1 inhibitor.
-
DescriptionTPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
-
SynonymsTPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1
-
PathwayOthers
-
TargetOther Targets
-
Recptorrecombinant SHP-1
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number79756-69-7
-
Formula Weight253.08
-
Molecular FormulaC12H6Cl2O2
-
Purity98%
-
SolubilityDMSO : 50 mg/mL 197.57 mM;
-
SMILESc1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl
-
Chemical Name2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
molnova catalog
related products
-
Fenchyl Alcohol
Fenchol is a hop-derived aroma compound commonly found in beer.
-
2-CHLOROMETHYL-1,1-D...
2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).
-
Formononetin-8-C-bet...
Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside is a natural product for research related to life sciences.