TPI-1

CAS No. 79756-69-7

TPI-1 ( TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1 )

Catalog No. M17598 CAS No. 79756-69-7

TPI-1 is a SHP-1 inhibitor.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 63 In Stock
5MG 105 In Stock
10MG 178 In Stock
25MG 348 In Stock
50MG 529 In Stock
100MG 754 In Stock
500MG 1548 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TPI-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TPI-1 is a SHP-1 inhibitor.
  • Description
    TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
  • Synonyms
    TPI-1; TPI 1;Tyrosine Phosphatase Inhibitor 1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    recombinant SHP-1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    79756-69-7
  • Formula Weight
    253.08
  • Molecular Formula
    C12H6Cl2O2
  • Purity
    98%
  • Solubility
    DMSO : 50 mg/mL 197.57 mM;
  • SMILES
    c1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl
  • Chemical Name
    2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
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