Cart
sales@molnova.com
TPI-1
CAS No. 79756-69-7
TPI-1( TPI-1 | TPI 1 | Tyrosine Phosphatase Inhibitor 1 )
Catalog No. M17598 CAS No. 79756-69-7
TPI-1 is a SHP-1 inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 63 | In Stock |
|
| 5MG | 105 | In Stock |
|
| 10MG | 178 | In Stock |
|
| 25MG | 348 | In Stock |
|
| 50MG | 529 | In Stock |
|
| 100MG | 754 | In Stock |
|
| 500MG | 1548 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTPI-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionTPI-1 is a SHP-1 inhibitor.
-
DescriptionTPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
-
In VitroSHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood.
-
In VivoTPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent.
-
SynonymsTPI-1 | TPI 1 | Tyrosine Phosphatase Inhibitor 1
-
PathwayOthers
-
TargetOther Targets
-
Recptorrecombinant SHP-1
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number79756-69-7
-
Formula Weight253.08
-
Molecular FormulaC12H6Cl2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO : 50 mg/mL 197.57 mM;
-
SMILESc1cc(c(cc1Cl)C1=CC(=O)C=CC1=O)Cl
-
Chemical Name2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.
molnova catalog
related products
-
Fas C-Terminal Tripe...
Fas C-Terminal Tripeptide is a C-terminal tripeptide of Fas. Fas C-Terminal Tripeptide shows the inhibitory effect on Fas/FAP-1 binding.
-
Chamaejasmenin B
Chamaejasmenin B is a compound isolated from Stellera chamaejasme L. Chamaejasmenin B has anticancer and antitumor activity, inhibiting cancer cell migration and invasion, and inhibiting tumor metastasis.Chamaejasmenin B is used in the study of cancers such as breast cancer.
-
Di-tert-butyl dicarb...
Di-tert-butyl dicarbonate(BOC anhydride) is a biochemical reagent that can be used in biochemical experiments.
