Cart
sales@molnova.com
Home - Products - Others - Other Targets - TMP-153

TMP-153

CAS No. 128831-46-9

TMP-153 ( TMP153 )

Catalog No. M11175 CAS No. 128831-46-9

TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 873 Get Quote
50MG 1782 Get Quote
100MG 2250 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    TMP-153
  • Note
    Research use only, not for human use.
  • Brief Description
    TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.
  • Description
    TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.Hypercholesterolemia Discontinued
  • Synonyms
    TMP153
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypercholesterolemia

Chemical Information

  • CAS Number
    128831-46-9
  • Formula Weight
    437.90
  • Molecular Formula
    C24H18ClF2N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1=CC2=C(C(=CN=C2C=C1C)NC(=O)NC3=C(C=C(C=C3)F)F)C4=CC=CC=C4Cl
  • Chemical Name
    N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.
2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.
3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AG-1557

    Detail unknown.

  • Dehydrodicatechin A

    The peroxidase-mediated (+)-catechin oxidation was differentially inhibited by dehydrodicatechin A, showing a competitive type inhibition and a k(I) of 6.4 microM.

  • 5-Hydroxy-4a,8-dimet...

    The herbs of Inula hupehensis.

Sign In Join Free