TM5441

CAS No. 1190221-43-2

TM5441 ( TM-5441;BMS790052; EBP883 )

Catalog No. M17864 CAS No. 1190221-43-2

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 43 In Stock
5MG 71 In Stock
10MG 110 In Stock
25MG 237 In Stock
50MG 444 In Stock
100MG 631 In Stock
500MG 1314 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TM5441
  • Note
    Research use only, not for human use.
  • Brief Description
    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
  • Description
    TM-5441, also known as EBP 883 and BMS-790052, is a potent plasminogen activator inhibitor-1 (PAI-1). TM-5441 inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. TM5441 protects against high-fat diet-induced obesity and adipocyte injury in mice.
  • Synonyms
    TM-5441;BMS790052; EBP883
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PAI-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190221-43-2
  • Formula Weight
    428.83
  • Molecular Formula
    C21H17ClN2O6
  • Purity
    98%
  • Solubility
    DMSO : ≥ 300 mg/mL; 699.59 mM
  • SMILES
    O=C(O)c3cc(Cl)ccc3NC(=O)COCC(=O)Nc1cccc(c1)c2ccco2
  • Chemical Name
    5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786.
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