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TM5441

CAS No. 1190221-43-2

TM5441 ( TM-5441;BMS790052; EBP883 )

Catalog No. M17864 CAS No. 1190221-43-2

TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 71 In Stock
10MG 110 In Stock
25MG 237 In Stock
50MG 444 In Stock
100MG 631 In Stock
500MG 1314 In Stock
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Biological Information

  • Product Name
    TM5441
  • Note
    Research use only, not for human use.
  • Brief Description
    TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
  • Description
    TM-5441, also known as EBP 883 and BMS-790052, is a potent plasminogen activator inhibitor-1 (PAI-1). TM-5441 inhibits several tumor cell lines with IC50 values between 9.7 and 60.3 μM. TM5441 protects against high-fat diet-induced obesity and adipocyte injury in mice.
  • Synonyms
    TM-5441;BMS790052; EBP883
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PAI-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1190221-43-2
  • Formula Weight
    428.83
  • Molecular Formula
    C21H17ClN2O6
  • Purity
    98%
  • Solubility
    DMSO : ≥ 300 mg/mL; 699.59 mM
  • SMILES
    O=C(O)c3cc(Cl)ccc3NC(=O)COCC(=O)Nc1cccc(c1)c2ccco2
  • Chemical Name
    5-chloro-2-(2-(2-((3-(furan-3-yl)phenyl)amino)-2-oxoethoxy)acetamido)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Placencio VR, et al. Small Molecule Inhibitors of Plasminogen Activator Inhibitor-1 Elicit Anti-Tumorigenic and Anti-Angiogenic Activity. PLoS One. 2015 Jul 24;10(7):e0133786.
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