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TLR7-agonist-1
CAS No. 1642857-69-9
TLR7-agonist-1( —— )
Catalog No. M18104 CAS No. 1642857-69-9
TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 228 | In Stock |
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| 5MG | 470 | In Stock |
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| 10MG | 680 | In Stock |
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| 25MG | 1053 | In Stock |
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| 50MG | 1422 | In Stock |
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| 100MG | 1917 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTLR7-agonist-1
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NoteResearch use only, not for human use.
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Brief DescriptionTLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
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DescriptionTLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
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In VitroTLR7 agonist 2 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a lowest effective concentration (LEC) of 0.4 μM in HEK293 cell. TLR7 agonist 2 is found to be selective for TLR7 over TLR8 with LEC of >100 μMfor human TLR8. TLR7 agonist 2 demonstrates low inhibition across five CYP450 isozymes (IC50 >10 μM) and is also not a time dependent inhibitor of CYP450 3A4. TLR7 agonist 2 has limited inhibition of the hERG potassium ion channel 3H-dofetilide binding in vitro (IC50 >50 μM).
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In VivoTLR7 agonist 2 is found to be rapidly cleared in conjunction with our target profile. Both Cmax and AUC increase less than dose proportionally between 0.3 and 3 mg/kg and more than dose-proportionally between 3 and 10 mg/kg. TLR7 agonist 2 can induce an antiviral interferon stimulated gene (ISG) response without inducing an IFNα response at a low dose. TLR7 agonist 2 also induces a 2.7 log decrease in serum HBV viral load from 0.3 mg/kg, and a maximum 3.1 log decrease is observed for doses between 1 and 5 mg/kg.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTLR7
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Research AreaInfection|Inflammation/Immunology
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Indication——
Chemical Information
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CAS Number1642857-69-9
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Formula Weight336.36
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Molecular FormulaC17H16N6O2
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Purity>98% (HPLC)
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SolubilityDMSO : 160 mg/mL 475.69 mM;
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SMILESCC1=CC(=NO1)COC2=NC(=NC3=C2N(C=C3)CC4=CC=CC=N4)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.McGowan DC, et al.. J Med Chem. 2017 Jul 27;60(14):6137-6151.
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