Cart
sales@molnova.com
TLR4-IN-C34
CAS No. 40592-88-9
TLR4-IN-C34( —— )
Catalog No. M21768 CAS No. 40592-88-9
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 34 | In Stock |
|
| 5MG | 55 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 120 | In Stock |
|
| 50MG | 194 | In Stock |
|
| 100MG | 286 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTLR4-IN-C34
-
NoteResearch use only, not for human use.
-
Brief DescriptionTLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
-
DescriptionTLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
-
In Vitro——
-
In VivoTLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa. Animal Model:Experimental NEC induced in 7-8 day old mice.Dosage:1 mg/kg.Administration:Orally every morning.Result:Attenuated intestinal inflammation.
-
Synonyms——
-
PathwayImmunology/Inflammation
-
TargetTLR
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number40592-88-9
-
Formula Weight389.4
-
Molecular FormulaC??H??NO?
-
Purity>98% (HPLC)
-
SolubilityDMSO : 250 mg/mL (642.01 mM; Need ultrasonic)
-
SMILESO=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.
2. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.
molnova catalog
related products
-
4-Methylayapin
4-Methylayapin
-
Polyinosinic-polycyt...
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).
-
Muscone
Muscone is an organic compound that is the primary contributor to the odor of musk.
