TK216

CAS No. 1903783-48-1

TK216 ( —— )

Catalog No. M22684 CAS No. 1903783-48-1

TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.In DLBCL cell lines, TK216 (500 nM; for 24-72 hours) induces apoptosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 140 In Stock
25MG 282 In Stock
50MG 484 In Stock
100MG 700 In Stock
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Biological Information

  • Product Name
    TK216
  • Note
    Research use only, not for human use.
  • Brief Description
    TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.In DLBCL cell lines, TK216 (500 nM; for 24-72 hours) induces apoptosis.
  • Description
    TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.In DLBCL cell lines, TK216 (500 nM; for 24-72 hours) induces apoptosis. TK216 (0.03, 0.06, 0.125, 0.25, 0.5 μM) results in a dose-dependent inhibition of proliferation in Ewing Sarcoma A4573 cell line. In DLBCL cell lines, TK216 (0.1, 0.3, 1 μM) induces apoptosis, with the amount of cleaved-Caspase 3 normalized to b-actin and presented as fold over control. TK216 has IC50s of 0.363 μM and 0.152 μM for the HL-60 AML cell line and TMD-8 DLBCL cell line. TK216 inhibits EWS-FLI1 (Ewing sarcoma breakpoint region 1/Friend leukemia virus integration 1 fusion protein) protein interactions, leading to a decrease in transcription and proliferation.In the TMD-8 xenograft model, TK216 (po; 100 mg/kg; twice daily for 13 days) results in tumor growth inhibition.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ETS
  • Research Area
    Cancer
  • Indication
    Recurrent Acute Myeloid Leukemia|Refractory Acute Myeloid Leukemia

Chemical Information

  • CAS Number
    1903783-48-1
  • Formula Weight
    376.23
  • Molecular Formula
    C19H15Cl2NO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:249 mg/mL(661.83 mM)
  • SMILES
    OC1(CC(=O)c2ccc(cc2)C2CC2)C(=O)Nc2c1c(Cl)ccc2Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
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