THZ2
CAS No. 1604810-84-5
THZ2 ( THZ-2 )
Catalog No. M12304 CAS No. 1604810-84-5
THZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 177 | In Stock |
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10MG | 245 | In Stock |
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25MG | 444 | In Stock |
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50MG | 647 | In Stock |
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100MG | 888 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameTHZ2
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NoteResearch use only, not for human use.
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Brief DescriptionTHZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1.
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DescriptionTHZ2, an analogue of THZ1 with improved pharmacokinetic features, is a potent, selective CDK7 inhibitor with IC50 of 13.9 nM, displays a 5-fold improved half-life in vivo compared with THZ1; selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR+ breast cancer cells, efficiently suppresses the clonogenic growth of TNBC cells with IC50 of 10 nM; Like THZ1, THZ2 induces apoptotic cell death in triple-negative but not ER/PR+ breast cancer cells or normal human cells; suppresses the growth of triple-negative breast tumors in xenograft models.
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SynonymsTHZ-2
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1604810-84-5
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Formula Weight566.05
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Molecular FormulaC31H28ClN7O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 39 mg/mL
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SMILESO=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5
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Chemical NameBenzamide, N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-3-[[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang Y, et al. Cell. 2015 Sep 24;163(1):174-86.
molnova catalog
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