THAL-SNS-032

CAS No. 2139287-33-3

THAL-SNS-032 ( THAL SNS 032;CDK9 PROTAC degrader )

Catalog No. M13415 CAS No. 2139287-33-3

THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 259 Get Quote
10MG 389 Get Quote
25MG 622 Get Quote
50MG 885 Get Quote
100MG 1197 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    THAL-SNS-032
  • Note
    Research use only, not for human use.
  • Brief Description
    THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).
  • Description
    THAL-SNS-032 is a novel CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN); efficiently induces complete CDK9 degradation at 250 nM (6h treatment), inhibits proliferation of MOLT4 cells at lower concentrations (IC50 = 50 nM) than SNS-032 (IC50=173 nM), exhibits more potent inhibition of proliferation than SNS-032 across a panel of 11 different leukemia cancer cell lines; induces rapid degradation of CDK9 without affecting the levels of other SNS-032 targets, and has prolonged cytotoxic effects.
  • Synonyms
    THAL SNS 032;CDK9 PROTAC degrader
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2139287-33-3
  • Formula Weight
    869.02
  • Molecular Formula
    C40H52N8O10S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1CCN(CC(NCCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)=O)CC1)NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5
  • Chemical Name
    N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(14-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-2-oxo-6,9,12-trioxa-3-azatetradecyl)piperidine-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Olson CM, et al. Nat Chem Biol. 2017 Dec 18. doi: 10.1038/nchembio.2538.
molnova catalog
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