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TH1760

CAS No. 2567914-01-4

TH1760( —— )

Catalog No. M36034 CAS No. 2567914-01-4

TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TH1760
  • Note
    Research use only, not for human use.
  • Brief Description
    TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).
  • Description
    TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.
  • In Vitro
    Western Blot Analysis Cell Line:HCT116 cells.Concentration:10 μM.Incubation Time:4 h.Result:Inhibited the expression of NUDT15.Western Blot Analysis Cell Line:AML HL-60 cells.Concentration:10 μM.Incubation Time: 3 h.Result:Significantly inhibited the expression of NUDT15 when the temperature was higher than 54℃.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    NUDIX hydrolase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2567914-01-4
  • Formula Weight
    426.45
  • Molecular Formula
    C20H18N4O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    S(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhang SM, et al. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16(10):1120-1128. ?
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