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TH1217

CAS No. 1862212-48-3

TH1217( —— )

Catalog No. M35023 CAS No. 1862212-48-3

TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TH1217
  • Note
    Research use only, not for human use.
  • Brief Description
    TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM.
  • Description
    TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.
  • In Vitro
    TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%).TH1217 presents suitable mouse microsomal half-lives (109 minutes).TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1862212-48-3
  • Formula Weight
    491.09
  • Molecular Formula
    C20H17BCl2N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (254.54 mM; Ultrasonic )
  • SMILES
    Cc1nc2c(c(Cl)c(Cl)cc2n1Cc1ccc(cc1)[B-]12OC(=O)C[N+]1(C)CC(=O)O2)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Llona-Minguez S, et, al. Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Med Chem. 2016 Feb 11; 59(3): 1140-1148.?
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