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TH-Z145
CAS No. 2260887-57-6
TH-Z145( —— )
Catalog No. M36529 CAS No. 2260887-57-6
TH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 110 | In Stock |
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| 5MG | 100 | In Stock |
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| 10MG | 163 | In Stock |
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| 25MG | 337 | In Stock |
|
| 50MG | 532 | In Stock |
|
| 100MG | 849 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTH-Z145
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NoteResearch use only, not for human use.
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Brief DescriptionTH-Z145 is a potent FPPS inhibitor for the study of myeloma and lung cancer.
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DescriptionTH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC50: 210 nM).
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In Vitro——
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In VivoTH-Z145 (20 μg, i.p.) exhibits strong prophylactic effects in a pathogenic influenza model.Animal Model:B16-OVA cells (s.c.) xenograft mice model.Dosage:20 μg Administration:Intraperitoneal injection (i.p.)Result:Inhibited tumor growth and prolonged survival.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2260887-57-6
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Formula Weight394.34
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Molecular FormulaC16H28O7P2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (253.59 mM; Ultrasonic )
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SMILESC(C(P(=O)(O)O)P(=O)(O)O)C1=CC(OCCCCCCCC)=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21. ?
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