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TGN020

CAS No. 51987-99-6

TGN020( —— )

Catalog No. M19928 CAS No. 51987-99-6

TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TGN020
  • Note
    Research use only, not for human use.
  • Brief Description
    TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.
  • Description
    TGN-020 is an inhibitor of Aquaporin 4 (AQP4 IC50: 3.1 μM) the most abundant water channel in the brain.(In Vitro):PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.(In Vivo):TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100?mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220?g, 9-10?weeks old) with SCI.
  • In Vitro
    PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. They are for reference only.
  • In Vivo
    TGN-020 (0.02 mg/μL; two microliter intravitreal injections) can suppress retinal edema in STZ-induced diabetic rats (nine-week-old male Wistar rats) retinas.TGN-020 (100?mg/kg; ip; single dose immediately followed SCI) promotes functional recovery at days 3, 7, 14, 21, and 28, as well as reduces the degree of edema and inhibits the expression of AQP4, GFAP, PCNA at days 3 after SCI. TGN-020 inhibits the glial scar formation and upregulates GAP-43 expression in adult female Sprague-Dawley rats (180-220?g, 9-10?weeks old) with SCI.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AQP4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    51987-99-6
  • Formula Weight
    206.22
  • Molecular Formula
    C8H6N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 8 mg/mL
  • SMILES
    O=C(Nc1nncs1)c1cccnc1
  • Chemical Name
    N-134-Thiadiazol-2-yl-3-pyridinecarboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Huber VJ et al. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg Med Chem. 2009 Jan 1;17(1):411-7.
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