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TED-347

CAS No. 2378626-29-8

TED-347 ( —— )

Catalog No. M21960 CAS No. 2378626-29-8

TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TED-347
  • Note
    Research use only, not for human use.
  • Brief Description
    TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
  • Description
    TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TEAD4-Yap1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2378626-29-8
  • Formula Weight
    313.7
  • Molecular Formula
    C15H11ClF3NO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:64 mg/ml(204.02 mM)
  • SMILES
    FC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
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