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TED-347

CAS No. 2378626-29-8

TED-347( —— )

Catalog No. M21960 CAS No. 2378626-29-8

TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.

TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TED-347
  • Note
    Research use only, not for human use.
  • Brief Description
    TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
  • Description
    TED-347 is an?irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
  • In Vitro
    Cell Viability Assay Cell Line:GBM43 glioblastoma cell lines Concentration:0.5, 1, 10, 100 μM Incubation Time:48 hoursResult:Inhibited GBM43 cancer cell viability and inhibited GBM43 cell viability by 30% at 10 μM.Western Blot Analysis Cell Line:HEK-293 cells Concentration:5 μM Incubation Time:48 hours Result:Showed a significant loss of co-immunoprecipitation of Myc-tagged TEAD4 with FLAG-tagged Yap1.RT-PCRCell Line:HEK-293 cells Concentration:10 μM Incubation Time:48 hours Result:Showed a significant reduction in CTGF transcript levels versus control cells and had no inhibition on TEAD mutant transcriptional activity and protein-protein interactions in cell culture.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TEAD4-Yap1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2378626-29-8
  • Formula Weight
    313.7
  • Molecular Formula
    C15H11ClF3NO
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:64 mg/ml(204.02 mM)
  • SMILES
    FC(F)(F)c1cccc(Nc2ccccc2C(=O)CCl)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD?Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
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