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TDI-011536
CAS No. 2687970-96-1
TDI-011536( —— )
Catalog No. M35339 CAS No. 2687970-96-1
TDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | Get Quote |
|
| 10MG | 76 | Get Quote |
|
| 25MG | 158 | Get Quote |
|
| 50MG | 256 | Get Quote |
|
| 100MG | 410 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTDI-011536
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NoteResearch use only, not for human use.
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Brief DescriptionTDI-011536, a potent Lats kinase inhibitor, disrupts Hippo-Yap signaling and promotes the proliferation of lesioned heart muscle cells. This compound is valuable for research in organ conservation and regeneration.
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DescriptionTDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
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In VitroCell Proliferation Assay Cell Line:human retinal organoids Concentration:3 μM Incubation Time:24 h, 5 days Result:Supressed Yap phosphorylation and promoted Müller glia proliferation.
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In VivoAnimal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).Dosage:200 mg/kg Administration:Intraperitoneal injections; once.Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.Animal Model:Male 8-week-old mice (cryolesion model).Dosage:100 mg/kg Administration:Intraperitoneal injections; once daily for 2 or 3 days.Result:Promoted cardiomyocytes proliferation.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2687970-96-1
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Formula Weight364.42
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Molecular FormulaC19H16N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (343.01 mM; Ultrasonic )
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SMILESOCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. ?
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