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TD-165

CAS No. 2305936-56-3

TD-165 ( —— )

Catalog No. M27017 CAS No. 2305936-56-3

TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a?CRBN?ligand binding group, a linker and a?VHL binding group.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TD-165
  • Note
    Research use only, not for human use.
  • Brief Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a?CRBN?ligand binding group, a linker and a?VHL binding group.
  • Description
    TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a?CRBN?ligand binding group, a linker and a?VHL binding group.(In Vitro):Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2305936-56-3
  • Formula Weight
    870.1
  • Molecular Formula
    C46H59N7O8S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)C(C)(C)C)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.XiaoyeGeng, et al. Design and fabrication of reversible thermochromic microencapsulated phase change materials for thermal energy storage and its antibacterial activity. Energy. Volume 159, 15 September 2018, Pages 857-869.
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