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TCDD
CAS No. 1746-01-6
TCDD( Dioxin | 2,3,7,8-Tetrachlorodibenzo-p-dioxin )
Catalog No. M12646 CAS No. 1746-01-6
A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameTCDD
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NoteResearch use only, not for human use.
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Brief DescriptionA potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway.
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DescriptionA potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway; suppresses the transcription of PEPCK and decreases Sirtuin 1 activation of PGC1α; also blocks cNK development and supports group 3 innate lymphoid cell (ILC3) differentiation.
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In Vitro——
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In Vivo——
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SynonymsDioxin | 2,3,7,8-Tetrachlorodibenzo-p-dioxin
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR
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Research Area——
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Indication——
Chemical Information
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CAS Number1746-01-6
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Formula Weight321.96
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Molecular FormulaC12H4Cl4O2
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Purity>98% (HPLC)
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Solubility——
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SMILESClC1=C(Cl)C=C2C(OC3=CC(Cl)=C(Cl)C=C3O2)=C1
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Chemical Name2,3,7,8-Tetrachlorodibenzo-p-dioxin
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ma Q, et al. J Biol Chem. 2000 Mar 24;275(12):8432-8.
2. Diani-Moore S, et al. J Biol Chem. 2013 Jul 26;288(30):21514-25.
3. Angelos MG, et al. Blood. 2017 Jun 29;129(26):3428-3439.
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