TCDD( Dioxin | 2,3,7,8-Tetrachlorodibenzo-p-dioxin )

Catalog No. M12646 CAS No. 1746-01-6

A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway.

Purity : >98% (HPLC)

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Biological Information

Product Name

TCDD
Note

Research use only, not for human use.
Brief Description

A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway.
Description

A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway; suppresses the transcription of PEPCK and decreases Sirtuin 1 activation of PGC1α; also blocks cNK development and supports group 3 innate lymphoid cell (ILC3) differentiation.
In Vitro

——
In Vivo

——
Synonyms

Dioxin | 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Pathway

Endocrinology/Hormones
Target

AhR
Recptor

AhR
Research Area

——
Indication

——

Chemical Information

CAS Number

1746-01-6
Formula Weight

321.96
Molecular Formula

C12H4Cl4O2
Purity

>98% (HPLC)
Solubility

——
SMILES

ClC1=C(Cl)C=C2C(OC3=CC(Cl)=C(Cl)C=C3O2)=C1
Chemical Name

2,3,7,8-Tetrachlorodibenzo-p-dioxin

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Ma Q, et al. J Biol Chem. 2000 Mar 24;275(12):8432-8. 2. Diani-Moore S, et al. J Biol Chem. 2013 Jul 26;288(30):21514-25. 3. Angelos MG, et al. Blood. 2017 Jun 29;129(26):3428-3439.

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