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TC11

CAS No. 100823-03-8

TC11( 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | CLT-003 )

Catalog No. M23213 CAS No. 100823-03-8

TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 50 In Stock
10MG 87 In Stock
25MG 178 In Stock
50MG 332 In Stock
100MG 494 In Stock
500MG 1071 In Stock
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Biological Information

  • Product Name
    TC11
  • Note
    Research use only, not for human use.
  • Brief Description
    TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
  • Description
    TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
  • In Vitro
    TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34.TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression.TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest. Cell Viability Assay Cell Line:KMS34 cells Concentration:0~30 μM Incubation Time:24 hours Result:Induced cell death.Western Blot Analysis Cell Line:KMS34 cells Concentration:5 μM Incubation Time:0~48 hours Result:Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression.Cell Cycle Analysis Cell Line:KMS34 cellsConcentration:5 μM Incubation Time:24 hours Result:Induced M arrest.
  • In Vivo
    ——
  • Synonyms
    1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 | CLT-003
  • Pathway
    Apoptosis
  • Target
    Caspase
  • Recptor
    caspase-3|caspase-8|caspase-9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    100823-03-8
  • Formula Weight
    322.4
  • Molecular Formula
    C20H22N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Di A , Mn A , Wm A , et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells - ScienceDirect[J]. Biochemical and Biophysical Research Communications, 2020, 521( 1):252-258.
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