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TAK-915

CAS No. 1476727-50-0

TAK-915 ( TAK915;TAK 915 )

Catalog No. M12037 CAS No. 1476727-50-0

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    TAK-915
  • Note
    Research use only, not for human use.
  • Brief Description
    TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
  • Description
    TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical
  • Synonyms
    TAK915;TAK 915
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1476727-50-0
  • Formula Weight
    458.37
  • Molecular Formula
    C19H18F4N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1C2=NC=C(OC)C=C2NC(C1)=O)N[C@@H](C3=CC=C(OC(F)(F)F)C(F)=C3)COC
  • Chemical Name
    N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
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