TAK-915 ( TAK915;TAK 915 )

Catalog No. M12037 CAS No. 1476727-50-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

TAK-915
Note

Research use only, not for human use.
Brief Description

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
Description

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM; dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms; robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats. Schizophrenia Phase 1 Clinical
Synonyms

TAK915;TAK 915
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Neurological Disease
Indication

Schizophrenia

CAS Number

1476727-50-0
Formula Weight

458.37
Molecular Formula

C19H18F4N4O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N1C2=NC=C(OC)C=C2NC(C1)=O)N[C@@H](C3=CC=C(OC(F)(F)F)C(F)=C3)COC
Chemical Name

N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.

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