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TAK-448

CAS No. 1234319-68-6

TAK-448( MVT-602 )

Catalog No. M29793 CAS No. 1234319-68-6

TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    TAK-448
  • Note
    Research use only, not for human use.
  • Brief Description
    TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.
  • Description
    TAK-448 (MVT-602) is a potent and full KISS1R agonist with an IC50 of 460 pM and an EC50 of 632 pM.TAK-448 has been used in trials studying the treatment of Prostate Cancer, Low Testosterone, Prostatic Neoplasms, and Hypogonadotropic Hypogonadism.(In Vivo):TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model.
  • In Vitro
    ——
  • In Vivo
    TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model. Animal Model:Rat VCaP xenograft androgen-sensitive prostate cancer model (7-week-old rats)Dosage:0.01, 0.03, 0.3, 3 mg/kg Administration:Given i.h.; dosings on day 0 and 28 Result:Had greater anti-tumor effects in VCaP xenograft model.
  • Synonyms
    MVT-602
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    IC50: 460 pM (KISS1R)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1234319-68-6
  • Formula Weight
    1225.36
  • Molecular Formula
    C58H80N16O14
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    Sequence:Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

Nishizawa N, et al. Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly PotentTestosterone-Suppressive Activity and Excellent Water Solubility. J Med Chem. 2016 Oct 13;59(19):8804-8811.
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