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TAK-259
CAS No. 1192348-73-4
TAK-259( TAK259 | TAK 259 )
Catalog No. M10667 CAS No. 1192348-73-4
A potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTAK-259
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively.
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DescriptionA potent and selective human α1D adrenoceptor (α1D-AR) antagonist with Ki of 1.1 nM; displays 200-fold and 800-fold selectivity against α1A- and α1B-AR, respectively; shows antagonistic activity by a bladder strip test in rats with bladder outlet obstruction, ameliorates cystitis-induced urinary frequency in rats.Other Indication Phase 1 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsTAK259 | TAK 259
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number1192348-73-4
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Formula Weight374.236
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Molecular FormulaC14H13Cl2N3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCS(=O)(=O)C1=C(C=C(C=C1)Cl)CN2C=C(C=C(C2=N)C(=O)N)Cl
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Chemical Name5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002.
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