TAK-063
CAS No. 1238697-26-1
TAK-063 ( TAK063;Balipodect )
Catalog No. M10959 CAS No. 1238697-26-1
TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 41 | In Stock |
|
5MG | 65 | In Stock |
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10MG | 85 | In Stock |
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25MG | 142 | In Stock |
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50MG | 243 | In Stock |
|
100MG | 421 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameTAK-063
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NoteResearch use only, not for human use.
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Brief DescriptionTAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM.
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DescriptionTAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes; increases cAMP and cGMP levels in the rodent striatum and upregulates phosphorylation levels of key substrates of cAMP- and cGMP-dependent protein kinases, strongly suppresses MK-801-induced hyperlocomotion in rodents (0.3 and 1 mg/kg p.o), improves cognitive functions associated with schizophrenia in rodent models,Schizophrenia Phase 2 Discontinued
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SynonymsTAK063;Balipodect
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE10A
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number1238697-26-1
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Formula Weight428.42
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Molecular FormulaC23H17FN6O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1C(C2=CC=NN2C3=CC=CC=C3)=NN(C4=CC=C(N5N=CC=C5)C=C4F)C=C1OC
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Chemical Name4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kunitomo J, et al. J Med Chem. 2014 Nov 26;57(22):9627-43.
2. Suzuki K, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9.
3. Shiraishi E, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):587-95.
4. Suzuki K, et al. Neuropsychopharmacology. 2016 Aug;41(9):2252-62.
2. Suzuki K, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9.
3. Shiraishi E, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):587-95.
4. Suzuki K, et al. Neuropsychopharmacology. 2016 Aug;41(9):2252-62.
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