TAK-063

CAS No. 1238697-26-1

TAK-063 ( TAK063;Balipodect )

Catalog No. M10959 CAS No. 1238697-26-1

TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 41 In Stock
5MG 65 In Stock
10MG 85 In Stock
25MG 142 In Stock
50MG 243 In Stock
100MG 421 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    TAK-063
  • Note
    Research use only, not for human use.
  • Brief Description
    TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM.
  • Description
    TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes; increases cAMP and cGMP levels in the rodent striatum and upregulates phosphorylation levels of key substrates of cAMP- and cGMP-dependent protein kinases, strongly suppresses MK-801-induced hyperlocomotion in rodents (0.3 and 1 mg/kg p.o), improves cognitive functions associated with schizophrenia in rodent models,Schizophrenia Phase 2 Discontinued
  • Synonyms
    TAK063;Balipodect
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE10A
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1238697-26-1
  • Formula Weight
    428.42
  • Molecular Formula
    C23H17FN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C1C(C2=CC=NN2C3=CC=CC=C3)=NN(C4=CC=C(N5N=CC=C5)C=C4F)C=C1OC
  • Chemical Name
    4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kunitomo J, et al. J Med Chem. 2014 Nov 26;57(22):9627-43.
2. Suzuki K, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9.
3. Shiraishi E, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):587-95.
4. Suzuki K, et al. Neuropsychopharmacology. 2016 Aug;41(9):2252-62.
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