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T6167923
CAS No. 1090528-71-4
T6167923( T 6167923 | T-6167923 )
Catalog No. M10343 CAS No. 1090528-71-4
T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameT6167923
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NoteResearch use only, not for human use.
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Brief DescriptionT6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production.
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DescriptionT6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM; specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein; dose-dependent in vivo therapeutic efficacy against SEB intoxication.
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In Vitro——
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In Vivo——
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SynonymsT 6167923 | T-6167923
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PathwayImmunology/Inflammation
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TargetMyD88
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RecptorMyD88
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Research Area——
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Indication——
Chemical Information
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CAS Number1090528-71-4
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Formula Weight458.389
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Molecular FormulaC17H20BrN3O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(N1CCN(S(=O)(C2=CC=CC(Br)=C2)=O)CC1)NC(C3=CC=CS3)C
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Chemical Name(S)-4-((3-bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Olson MA, et al. Sci Rep. 2015 Sep 18;5:14246.
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