Su1498

CAS No. 168835-82-3

Su1498 ( SU-1498; SU 1498; SU1498; Tyrphostin SU 1498 )

Catalog No. M17363 CAS No. 168835-82-3

SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 42 In Stock
5MG 65 In Stock
10MG 110 In Stock
25MG 210 In Stock
50MG 311 In Stock
100MG 462 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Su1498
  • Note
    Research use only, not for human use.
  • Brief Description
    SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).
  • Description
    SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1, 2 It effectively blocks signaling through VEGFR2 both in vitro and in vivo.1, 3 SU 1498 is used to study the role of VEGFR2 signaling in diverse processes, including angiogenesis, tumor growth, neural progenitor cell survival, and neuroregeneration.
  • Synonyms
    SU-1498; SU 1498; SU1498; Tyrphostin SU 1498
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    VEGFR2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    168835-82-3
  • Formula Weight
    390.53
  • Molecular Formula
    C25H30N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 150 mg/mL. 384.10 mM
  • SMILES
    O=C(/C(=C/c1cc(C(C)C)c(O)c(C(C)C)c1)/C#N)NCCCc1ccccc1
  • Chemical Name
    (2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1: Gawlak G, et al.Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1062-70.
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