Stepharine( —— )

Catalog No. M21805 CAS No. 2810-21-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Stepharine
Note

Research use only, not for human use.
Brief Description

Alkaloids.
Description

Alkaloids.
In Vitro

Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.
In Vivo

Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex. Animal Model:Middle cerebral artery occlusion (MCAO) rat model.Dosage:500 μg/kg (20 μL)Administration:Intranasally injected into rats 1h after MCAO.Result:Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

——
Research Area

——
Indication

——

CAS Number

2810-21-1
Formula Weight

297.3
Molecular Formula

C18H19NO3
Purity

>98% (HPLC)
Solubility

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES

COC1=C(C2=C3C(CC24C=CC(=O)C=C4)NCCC3=C1)OC
Chemical Name

10,11-dimethoxyspiro[5-azatricyclo[6.3.1.04,12]dodeca-1(12),8,10-triene-2,4'-cyclohexa-2,5-diene]-1'-one