Spiramycin

CAS No. 8025-81-8

Spiramycin( Formacidine | NSC 55926 | Rovamycine )

Catalog No. M16005 CAS No. 8025-81-8

A macrolide antibiotic produced by Streptomyces ambofaciens.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Spiramycin
  • Note
    Research use only, not for human use.
  • Brief Description
    A macrolide antibiotic produced by Streptomyces ambofaciens.
  • Description
    A macrolide antibiotic produced by Streptomyces ambofaciens. The drug is effective against gram-positive aerobic pathogens, N. gonorrhoeae, and staphylococci. It is used to treat infections caused by bacteria and Toxoplasma gondii. (In Vitro):Spiramycin (24 hours; 1-1000 μM; T. gondii infected HeLa cells and HeLa cells) treatment reduces the cytotoxicity, and shows anti-Toxoplasma gondii activity, with IC50 values of 189 μM for HeLa cells; and 262 μM for T. gondii-infected HeLa cells.(In Vivo):Spiramycin (100 mg/kg; intraperitoneal injection; every day; for 4 days; female KM mice) treatment reduces the number of tachyzoites, and reduces hepatotoxicity and significantly enhances antioxidative effects. Spiramycin treatment also decreases in the degree of granulomatous inflammation in the liver.
  • In Vitro
    Spiramycin (24 hours; 1-1000 μM; T. gondii infected HeLa cells and HeLa cells) treatment reduces the cytotoxicity, and shows anti-Toxoplasma gondii activity, with IC50 values of 189 μM for HeLa cells; and 262 μM for T. gondii-infected HeLa cells. Cell Cytotoxicity Assay Cell Line:T. gondii infected HeLa cells and HeLa cells Concentration:1-1000 μM Incubation Time:24 hours Result:Reduced the cytotoxicity.
  • In Vivo
    Spiramycin (100 mg/kg; intraperitoneal injection; every day; for 4 days; female KM mice) treatment reduces the number of tachyzoites, and reduces hepatotoxicity and significantly enhances antioxidative effects. Spiramycin treatment also decreases in the degree of granulomatous inflammation in the liver. Animal Model:36 female KM mice with T.gondiiDosage:100 mg/kgAdministration:Intraperitoneal injection; every day; for 4 daysResult:The number of tachyzoites was significantly reduced. Reduced hepatotoxicity and significantly enhanced antioxidative effects. Granuloma and cyst formation were inhibitied.
  • Synonyms
    Formacidine | NSC 55926 | Rovamycine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    8025-81-8
  • Formula Weight
    843.07
  • Molecular Formula
    C43H74N2O14
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 100 mg/mL (118.61 mM); DMSO: 100 mg/mL (118.61 mM)
  • SMILES
    C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)O)(C)O)N(C)C)O)CC=O)C)OC4CCC(C(O4)C)N(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Poulsen SM, et al. J Mol Biol, 2000, 304(3), 471-48
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