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Solamargine

CAS No. 20311-51-7

Solamargine( Solamargin | δ-Solanigrine )

Catalog No. M17419 CAS No. 20311-51-7

Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Solamargine
  • Note
    Research use only, not for human use.
  • Brief Description
    Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
  • Description
    Solamargine is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
  • In Vitro
    Solamargine (15 μg/ml; 72 hours) predominantly stimulates the cells of the G2/M phase to apoptosis.Solamargine (72 hours) dramatically inhibits the proliferation of SMMC-7721 and HepG2 cells in a dose- and time-dependent manner. The IC50s are 9.21 and 19.88 μg/ml, respectively. Cell Viability Assay Cell Line:SMMC-7721cells Concentration:15 μg/ml.Incubation Time:72 hours Result:Displayed a significant increase of sub-G1.
  • In Vivo
    Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo. Animal Model:Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old) Dosage:10 mg/kg Administration:Intragastric administration; once daily for 8 days Result:Tumor growth was significantly inhibited .
  • Synonyms
    Solamargin | δ-Solanigrine
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    p38 MAPK| STAT3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    20311-51-7
  • Formula Weight
    868.07
  • Molecular Formula
    C45H73NO15
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 8.8 mg/mL; 10.14 mM
  • SMILES
    [C@H]1([C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)NC[C@@H](CC6)C)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O)O[C@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)CO
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sani IK., et al. Toxicol In Vitro. 2015 Aug;29(5):893-900.
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