Sofalcone

CAS No. 64506-49-6

Sofalcone( SU-88 )

Catalog No. M19821 CAS No. 64506-49-6

Sofalcone a gastric antiulcer agent in clinical use is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 43 In Stock
200MG 53 In Stock
500MG 73 In Stock
1G 105 In Stock

Biological Information

  • Product Name
    Sofalcone
  • Note
    Research use only, not for human use.
  • Brief Description
    Sofalcone a gastric antiulcer agent in clinical use is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.
  • Description
    Sofalcone a gastric antiulcer agent in clinical use is known to induce the expression of Heme oxygenase-1 (HO-1) in gastric epithelium.(In Vitro):Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression compare with the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis demonstrates that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs.
  • In Vitro
    Sofalcone (50 μmol/L) significantly increases HO-1 mRNA expression compare with the control group in both trophoblasts and HUVECs (P<0.05 for both). Western blot analysis demonstrates that Sofalcone potently increases HO-1 protein expression in primary HUVECs treated for 24 hours. Western blot analysis also reveals a significant increase in the amount of Nrf2 in the nuclear fraction of HUVECs with Sofalcone treatment (50 μmol/L) for 6 hours. In primary HUVECs, expression of NQO1, TXN, and GCLC are increased in a dose dependently manner with Sofalcone treatment for 24 hours. Sofalcone significantly decreases the sFlt-1 concentrations in the culture media and dose dependently decreases the amount of THP-1 monocyte adherence to HUVECs.
  • In Vivo
    ——
  • Synonyms
    SU-88
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Heme oxygenase-1
  • Research Area
    Inflammation/Immunology
  • Indication
    gastroenteritis and ulcers

Chemical Information

  • CAS Number
    64506-49-6
  • Formula Weight
    450.52
  • Molecular Formula
    C27H30O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    C\C(C)=C\COc1ccc(\C=C\C(=O)c2ccc(OC\C=C(\C)C)cc2OCC(O)=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Onda K et al. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway reduces soluble fms-like tyrosine kinase-1 and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015 Apr;65(4):855-62.
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