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Sirt2-PROTAC-1

CAS No. 2098487-75-1

Sirt2-PROTAC-1( Sirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1 )

Catalog No. M13316 CAS No. 2098487-75-1

A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Sirt2-PROTAC-1
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
  • Description
    A novel SirReal-based PROTAC that induces isotype-selective Sirt2 degradation (IC50=0.25 uM).
  • In Vitro
    Western Blot Analysis Cell Line:HeLa cells Concentration:10 μM Incubation Time:1-6 hours Result:Caused Sirt2 degradation, but showed no effect on Sirt1 levels.
  • In Vivo
    ——
  • Synonyms
    Sirt2-PROTAC-1 | Sirt2 PROTAC-1 | Sirt2-PROTAC1
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2098487-75-1
  • Formula Weight
    852.942
  • Molecular Formula
    C40H40N10O8S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 100 mg/mL 117.24 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C(NC1=NC=C(CC2=CC=CC(OCC3=CN(CCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)N=N3)=C2)S1)CSC7=NC(C)=CC(C)=N7
  • Chemical Name
    2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(3-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methoxy)benzyl)thiazol-2-yl)acetamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schiedel M, et al. J Med Chem. 2017 Apr 17. doi: 10.1021/acs.jmedchem.6b01872.
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