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Sinefungin
CAS No. 58944-73-3
Sinefungin( Adenosyl-Ornithine | A-9145 | Antibiotic 32232RP )
Catalog No. M24582 CAS No. 58944-73-3
Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 282 | In Stock |
|
| 50MG | 1674 | In Stock |
|
| 100MG | 2943 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSinefungin
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NoteResearch use only, not for human use.
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Brief DescriptionSinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
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DescriptionSinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
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In VitroSinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells. Western Blot Analysis Cell Line:Renal epithelial cells.Concentration:0.5 or 1.0 μg/mL.Incubation Time:Pretreatment 60 minutes before TGF-β1 (10 ng/mL).Result:Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
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In VivoSinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy. Animal Model:Male C57BL/6J mice (8 weeks of age).Dosage:10 mg/kg Administration:Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).Result:Inhibited α-SMA protein expression.Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
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SynonymsAdenosyl-Ornithine | A-9145 | Antibiotic 32232RP
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PathwayOthers
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TargetOther Targets
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RecptorSET7/9
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Research Area——
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Indication——
Chemical Information
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CAS Number58944-73-3
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Formula Weight381.39
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Molecular FormulaC15H23N7O5
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Purity>98% (HPLC)
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SolubilityH2O:95 mg/mL (249.09 mM; Need ultrasonic)
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SMILESN[C@H](CC[C@H](C(O)=O)N)C[C@@H]([C@@H]([C@@H]1O)O)O[C@@H]1n1c2ncnc(N)c2nc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.
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