Sinefungin ( Adenosyl-Ornithine; A-9145; Antibiotic 32232RP )

Catalog No. M24582 CAS No. 58944-73-3

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Sinefungin
Note

Research use only, not for human use.
Brief Description

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.
Description

Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
Synonyms

Adenosyl-Ornithine; A-9145; Antibiotic 32232RP
Pathway

Others
Target

Other Targets
Recptor

SET7/9
Research Area

——
Indication

——

Chemical Information

CAS Number

58944-73-3
Formula Weight

381.4
Molecular Formula

C15H23N7O5
Purity

>98% (HPLC)
Solubility

H2O:95 mg/mL (249.09 mM; Need ultrasonic)
SMILES

N[C@H](CC[C@H](C(O)=O)N)C[C@@H]([C@@H]([C@@H]1O)O)O[C@@H]1n1c2ncnc(N)c2nc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7.

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