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Silodosin

CAS No. 160970-54-7

Silodosin ( KAD 3213;KMD 3213 )

Catalog No. M12319 CAS No. 160970-54-7

A highly potent, uroselective α1a-adrenoceptor antagonist with Ki of 36 pM; displays 583- and 56-fold lower potency against α1b and α1d respectors, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Silodosin
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly potent, uroselective α1a-adrenoceptor antagonist with Ki of 36 pM; displays 583- and 56-fold lower potency against α1b and α1d respectors, respectively.
  • Description
    A highly potent, uroselective α1a-adrenoceptor antagonist with Ki of 36 pM; displays 583- and 56-fold lower potency against α1b and α1d respectors, respectively; inhibits norepinephrine-induced increases intracellular Ca2+ concentrations in CHO cells with IC50 of 0.32 nM; inhibits intraurethral pressure (IUP) response in vivo.Other Indication Approved
  • Synonyms
    KAD 3213;KMD 3213
  • Pathway
    Angiogenesis
  • Target
    Adrenergic Receptor
  • Recptor
    β-adrenergicreceptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    160970-54-7
  • Formula Weight
    495.53
  • Molecular Formula
    C25H32F3N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=CC(C[C@H](NCCOC2=CC=CC=C2OCC(F)(F)F)C)=CC3=C1N(CCCO)CC3)N
  • Chemical Name
    1H-Indole-7-carboxamide, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shibata K, et al. Mol Pharmacol. 1995 Aug;48(2):250-8.
2. Yamagishi R, et al. Eur J Pharmacol. 1996 Nov 7;315(1):73-9.
3. Yamada S, et al. Life Sci. 1998;62(17-18):1585-9.
4. Akiyama K, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):81-91.
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